Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties.

Muhammad Saalim, Jessica Villegas-Moreno, Benjamin R Clark

Molecules (Basel, Switzerland) 2020 Dec 02

filter terms:

The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of this class of compounds dates back to the 1940s, when a range of alkylquinolones with notable antibiotic properties were first isolated from Pseudomonas aeruginosa. More recently, it was discovered that an alkylquinolone derivative, the Pseudomonas Quinolone Signal (PQS) plays a key role in bacterial communication and quorum sensing in Pseudomonas aeruginosa. Many of the best-studied examples contain simple hydrocarbon side-chains, but more recent studies have revealed a wide range of structurally diverse examples from multiple bacterial genera, including those with aromatic, isoprenoid, or sulfur-containing side-chains. In addition to their well-known antimicrobial properties, alkylquinolones have been reported with antimalarial, antifungal, antialgal, and antioxidant properties. Here we review the structural diversity and biological activity of these intriguing metabolites.

Citation

Muhammad Saalim, Jessica Villegas-Moreno, Benjamin R Clark. Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties. Molecules (Basel, Switzerland). 2020 Dec 02;25(23)