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It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which is known as the most common cause of dementia, is one of the top medical care concerns across the world. Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Aβ) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going to review studies that targeted inhibition of amyloid plaque and tau protein tangle formation, to suppress or postpone AD. Copyright © 2020 Elsevier B.V. All rights reserved.


Hossein Ashrafian, Elaheh Hadi Zadeh, Rizwan Hasan Khan. Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation. International journal of biological macromolecules. 2021 Jan 15;167:382-394

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PMID: 33278431

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