AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.

O M Ivko, N S Linkova, A R Ilina, A A Sharova, G A Ryzhak

Advances in gerontology = Uspekhi gerontologii 2020

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Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging. One of the promising geroprotectors restoring the pineal melatonin synthesis is the AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people. Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times and increases the Cry2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function. The geroprotective effect of the AEDG peptide is based on its ability to restore the epiphysis melatonin-producing function by means regulation of human circadian genes expression.

Citation

O M Ivko, N S Linkova, A R Ilina, A A Sharova, G A Ryzhak. AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging. Advances in gerontology = Uspekhi gerontologii. 2020;33(3):429-435