Saccharomyces boulardii as therapeutic alternative in experimental giardiasis.

M R S Ribeiro, D R Oliveira, M V Caliari, D C Cara Machado, M E R Andrade, V N Cardoso, F Dos Santos Martins, J R Nicoli, M A Gomes

Journal of applied microbiology 2021 Jul

filter terms:

The objective of this study was to evaluate the effect of treatment with the probiotic Saccharomyces boulardii with or without metronidazole in experimental giardiasis. The effect of treatment with S. boulardii with or without metronidazole on the intestinal mucosa, the antioxidant defence system and the parasitic load was determined in experimental giardiasis. Eight groups of animals with infection and/or treatment with the probiotic and/or drugs for 1 week after infection with Giardia lamblia were used. A reduction of approximately 90% in the parasitic load was observed in all the treated groups. Saccharomyces boulardii attenuated the damage caused by infection in the intestinal mucosa preserving its architecture and inhibiting the oxidative stress induced by parasite and metronidazole. Saccharomyces boulardii was effective alone or in combination with metronidazole in resolving already established G. lamblia infection. These results suggest the use of S. boulardii as an alternative treatment for giardiasis mainly in cases of resistance or intolerance to conventional treatment. © 2020 The Society for Applied Microbiology.

Citation

M R S Ribeiro, D R Oliveira, M V Caliari, D C Cara Machado, M E R Andrade, V N Cardoso, F Dos Santos Martins, J R Nicoli, M A Gomes. Saccharomyces boulardii as therapeutic alternative in experimental giardiasis. Journal of applied microbiology. 2021 Jul;131(1):460-469