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Neuroendocrine differentiation is characterized by endocrine and neuronal features with prominent dense secretory granules and neuropeptides. Neuroendocrine differentiation of skin tumors is of unknown clinical significance. Nonetheless, the acknowledgment of this line of differentiation is important to prevent diagnostic pitfalls and subsequent inappropriate management. This review aims at summarizing the skin neoplasms that can express neuroendocrine markers.


Lamiaa Hamie, Ossama Abbas, Jag Bhawan. Neuroendocrine Differentiation of Skin Tumors: A Comprehensive Review. The American Journal of dermatopathology. 2020 Dec;42(12):899-910

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PMID: 33289975

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