Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones.
Alexander A Fadeev, Alexey O Chagarovskiy, Anton S Makarov, Irina I Levina, Olga A Ivanova, Maxim G Uchuskin, Igor V Trushkov
Molecules (Basel, Switzerland) 2020 Dec 05A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor-acceptor cyclopropane family, has been developed. This method, based on the Corey-Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.
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Alexander A Fadeev, Alexey O Chagarovskiy, Anton S Makarov, Irina I Levina, Olga A Ivanova, Maxim G Uchuskin, Igor V Trushkov. Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones. Molecules (Basel, Switzerland). 2020 Dec 05;25(23)
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PMID: 33291488
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