Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

According to data provided by WHO (World Health Organization), hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. Since the approval of sorafenib in 2008, several trials have assessed other particles for the treatment of HCC, but few have proven to be effective. ESMO (European Society for Medical Oncology) guidelines have been changed several times recently. This systematic review aims to describe both successful and failed trials of systemic treatments for HCC. Methods: We examined randomized, phase III trials of first- and second-line treatments in adults, identifying 23 fully-published trials and 2 reported as abstracts. The latest advances in immunotherapy were also briefly discussed. Conclusions: The landscape of HCC treatment has changed significantly in recent years. Several small molecule inhibitors currently form the core of HCC treatment; however, immunotherapy is now emerging as a promising treatment option. Copyright © 2020 Elsevier B.V. All rights reserved.


Maciej Gryziak, Krzysztof Woźniak, Leszek Kraj, Rafał Stec. Milestones in the treatment of hepatocellular carcinoma: A systematic review. Critical reviews in oncology/hematology. 2021 Jan;157:103179

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 33302158

View Full Text