Forkhead Transcription Factors in Health and Disease.

Laetitia Herman, Anne-Laure Todeschini, Reiner A Veitia

Trends in genetics : TIG 2021 May

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Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Laetitia Herman, Anne-Laure Todeschini, Reiner A Veitia. Forkhead Transcription Factors in Health and Disease. Trends in genetics : TIG. 2021 May;37(5):460-475