Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis.

Craig J McClain, Vatsalya Vatsalya, Mack C Mitchell

The American journal of gastroenterology 2021 Jan 01

filter terms:

It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree. Copyright © 2020 by The American College of Gastroenterology.

Citation

Craig J McClain, Vatsalya Vatsalya, Mack C Mitchell. Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis. The American journal of gastroenterology. 2021 Jan 01;116(1):77-79