Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer.

Snehal Nirgude, Bibha Choudhary

Biochemical pharmacology 2021 Feb

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Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 GPxs, GPx3, a highly conserved protein and a major ROS scavenger in plasma, has been well studied and confirmed to play a vital role as a tumor suppressor in most cancers. Additionally, this gene is known to be epigenetically regulated. It is downregulated either by hypermethylation or genomic deletion. In this review, we summarized the role of GPX3 in various cancers, its use as a prognostic biomarker, and a potential target for clinical intervention. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Snehal Nirgude, Bibha Choudhary. Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer. Biochemical pharmacology. 2021 Feb;184:114365