Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases.

Alessandro Galgani, Francesco Lombardo, Daniele Della Latta, Nicola Martini, Ubaldo Bonuccelli, Francesco Fornai, Filippo Sean Giorgi

Current neurology and neuroscience reports 2020 Dec 12

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Locus coeruleus (LC) is the main noradrenergic nucleus of the brain, and its degeneration is considered to be key in the pathogenesis of neurodegenerative diseases. In the last 15 years,MRI has been used to assess LC in vivo, both in healthy subjects and in patients suffering from neurological disorders. In this review, we summarize the main findings of LC-MRI studies, interpreting them in light of preclinical and histopathological data, and discussing its potential role as diagnostic and experimental tool. LC-MRI findings were largely in agreement with neuropathological evidences; LC signal showed to be not significantly affected during normal aging and to correlate with cognitive performances. On the contrary, a marked reduction of LC signal was observed in patients suffering from neurodegenerative disorders, with specific features. LC-MRI is a promising tool, which may be used in the future to explore LC pathophysiology as well as an early biomarker for degenerative diseases.

Citation

Alessandro Galgani, Francesco Lombardo, Daniele Della Latta, Nicola Martini, Ubaldo Bonuccelli, Francesco Fornai, Filippo Sean Giorgi. Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases. Current neurology and neuroscience reports. 2020 Dec 12;21(1):2