mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses.

Basil S Karam, Rachel S Morris, Carolyn T Bramante, Michael Puskarich, Emily J Zolfaghari, Sahar Lotfi-Emran, Nicholas E Ingraham, Anthony Charles, David J Odde, Christopher J Tignanelli

Journal of medical virology 2021 Apr

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In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019. © 2020 Wiley Periodicals LLC.

Citation

Basil S Karam, Rachel S Morris, Carolyn T Bramante, Michael Puskarich, Emily J Zolfaghari, Sahar Lotfi-Emran, Nicholas E Ingraham, Anthony Charles, David J Odde, Christopher J Tignanelli. mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses. Journal of medical virology. 2021 Apr;93(4):1843-1846