Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans: 18F-FDG PET/CT Revealing the Infection and Assessing Treatment Response.

Billal Tedbirt, Anne-Benedicte Duval-Modeste, Philippe Courville, Stéphane Dominique, Pierre Vera, Hamza Regaieg

Clinical nuclear medicine 2021 Apr 01

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A 56-year-old woman, with history of psoriasis well controlled on ustekinumab, underwent 18F-FDG PET/CT to explore first onset of histologically proven skin panniculitis of unknown origin. PET/CT showed high uptake in panniculitis lesions in limbs and in a lung opacity suggestive of pneumonia. Based on PET/CT findings, a bronchoalveolar lavage revealed pulmonary coinfection by Pneumocystis jirovecii and Cryptococcus neoformans. Thus, hematogenous dissemination of infection was suspected as etiology of panniculitis. She was treated with fluconazole and trimethoprim-sulfamethoxazole, leading to total resolution of skin lesions. Posttherapeutic PET/CT showed complete metabolic response of skin and pulmonary lesions. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Billal Tedbirt, Anne-Benedicte Duval-Modeste, Philippe Courville, Stéphane Dominique, Pierre Vera, Hamza Regaieg. Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans: 18F-FDG PET/CT Revealing the Infection and Assessing Treatment Response. Clinical nuclear medicine. 2021 Apr 01;46(4):e210-e211