Low-dose cadmium stress increases the bioaccumulation and toxicity of dinotefuran enantiomers in zebrafish (Danio rerio)?

Shanshan Di, Peipei Qi, Shenggan Wu, Zhiwei Wang, Huiyu Zhao, Xueping Zhao, Xiangyun Wang, Hao Xu, Xinquan Wang

Environmental pollution (Barking, Essex : 1987) 2021 Jan 15

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Co-occurrence of pesticides and heavy metals has attracted extensive attention. The enantioselective behaviors of dinotefuran to aquatic organisms have not been reported, and the effects of cadmium (Cd) was absent, which were investigated in this study at environmentally relevant concentrations. The enantioselective accumulation and elimination of dinotefuran enantiomers were observed in zebrafish, and it had tissue specificity. The S-dinotefuran concentrations were higher than R-dinotefuran in heads and viscera, but it was opposite in muscles. There existed competition between S-dinotefuran and R-dinotefuran, and the existence of S-dinotefuran might decrease the accumulation and elimination of the R-dinotefuran in zebrafish. When co-exposure to Cd and dinotefuran, the accumulation concentrations of dinotefuran enantiomers increased in zebrafish at the initial stage, which were opposite latterly. The accumulation concentrations of R-dinotefuran in R + Cd treatment in fish were 3.4 times higher than those in R-dinotefuran treatment, and the enantiomer fraction (EF) values changed from 0.484 to 0.195. The oxidative stress of S-dinotefuran on zebrafish was highest, followed by rac- and R-dinotefuran. Co-exposure to Cd led to toxicity increase for R-dinotefuran, the malonaldehyde (MDA) content decreased significantly in R + Cd treatment during 7-28 days, while obvious declination of MDA contents was found on the 28th day in R-dinotefuran treatment. Furthermore, compared to R-dinotefuran treatment, Cd increased the relative expression of cz-sod (3.4 times), cas3 (1.6 times) and p53 (5.7 times) in R + Cd treatment. The co-exposure of Cd might alter the environmental behaviors and toxicity effects of dinotefuran enantiomers in zebrafish, including the enantioselectivity. The effects of Cd on accumulation and toxicity of R-dinotefuran were greater than those on S-dinotefuran. Thus, it is necessary to consider the effects of coexistent metals to chiral pesticides in ecological risk. SUMMARIZES: The enantioselective accumulation and elimination of dinotefuran enantiomers had tissue specificity. Cd increased the accumulation and toxicity of R-dinotefuran in zebrafish. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Shanshan Di, Peipei Qi, Shenggan Wu, Zhiwei Wang, Huiyu Zhao, Xueping Zhao, Xiangyun Wang, Hao Xu, Xinquan Wang. Low-dose cadmium stress increases the bioaccumulation and toxicity of dinotefuran enantiomers in zebrafish (Danio rerio)? Environmental pollution (Barking, Essex : 1987). 2021 Jan 15;269:116191