Twisting gating residues in the Orai pore.

Daniel Bonhenry, Romana Schober, Rainer Schindl

Cell calcium 2021 Jan

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The store-operated calcium channels Orai1-3 form extraordinary long and funnel like pores, in stark contrast to a classical pore loop architecture. A hydrophobic segment centrally located in the Orai pore controls gating. Here, we comment on a recent work that describes decisive binding between three residues that controls the open and closed conformation of Orai channels. Copyright © 2020 Elsevier Ltd. All rights reserved.