Rifabutin Is Inactivated by Mycobacterium abscessus Arr.

Daniel Schäfle, Petra Selchow, Barbara Borer, Michael Meuli, Anna Rominski, Bettina Schulthess, Peter Sander

Antimicrobial agents and chemotherapy 2021 Feb 17

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Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessus Δarr revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity. Copyright © 2021 American Society for Microbiology.

Citation

Daniel Schäfle, Petra Selchow, Barbara Borer, Michael Meuli, Anna Rominski, Bettina Schulthess, Peter Sander. Rifabutin Is Inactivated by Mycobacterium abscessus Arr. Antimicrobial agents and chemotherapy. 2021 Feb 17;65(3)