Tumor-Derived PGE2 Gives NK Cells a Headache.

Nelson H Knudsen, Robert T Manguso

Immunity 2020 Dec 15

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Tumors use active immunosuppressive mechanisms to evade immune recognition and shape the local inflammatory environment. In this issue of Immunity, Bonavita et al. report that tumor-derived PGE2 blocks early activation of natural killer cells and interferes with subsequent adaptive immune cell recruitment to the tumor. Copyright © 2020 Elsevier Inc. All rights reserved.