Allogeneic uterus transplantation in a rhesus model: A short-term graft viability study.

Bo Yu, Zhongyu Liu, Chunyu Zhang, Yu Wu, Jinsong Han, Huajun Li, Bing Xu, Hongyan Guo, Kun Zhang

PloS one 2020

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This study examined the feasibility and safety of allogeneic uterus transplantation (UTx) from a living donor and assessed short-term graft viability in a rhesus model. This research is an important step towards further clinical application of UTx in humans. Four female rhesus monkeys with regular menstrual cycles were used in this study, the animals were either donors or recipients depending on ABO blood type compatibility. Retrieval surgery was performed to connect the uterus and uterine arteries together with the ovarian uterine vein from the living donor, and the vagina of the recipient was excised. After the back table had been prepared, bilateral uterine arteries were anastomosed end-to-side with the iliac externa arteries, and bilateral ovarian uterine veins were anastomosed end-to-side with the iliac externa vena. The transplanted uterus was evaluated based on the conditions of arterial blood, and flow was evaluated by transabdominal ultrasonography one month post operation. The conditions of the transplanted uterus were examined by secondary laparotomy. The reproductive function of rhesus monkeys was evaluated on the basis of the menstrual cycle. All 4 rhesus monkeys received the transplantation surgery without any surgical complications. No injury occurred in the other organs, and no vascular injury was observed in the allogeneic uterus. All recipients survived after the surgery with a 100% short-term survival rate. All recipients resumed normal menstruation within two months after surgery. Our short follow-up shows that allogeneic UTx surgery is a safe and feasible technology in the rhesus model. The arterial conditions and blood flow of the grafted uterus can be monitored by ultrasonography examination.

Citation

Bo Yu, Zhongyu Liu, Chunyu Zhang, Yu Wu, Jinsong Han, Huajun Li, Bing Xu, Hongyan Guo, Kun Zhang. Allogeneic uterus transplantation in a rhesus model: A short-term graft viability study. PloS one. 2020;15(12):e0243140