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Chronic rhinosinusitis may be associated with nasal polyposis. Recurrence of disease is often observed and may be due to an intolerance of acetylsalicylic acid. Sex hormones are known to modulate allergic reactions and inflammation. Whether they may be involved in the development and progression of nasal polyposis has not been investigated yet. Examine the relationship between levels of sex hormones and nasal polyposis. Hormonal levels (estradiol, testosterone and progesterone) in patients with nasal polyposis (n = 26) with or without acetylsalicylic acid-intolerance were determined and compared to hormonal levels in patients with septal deviation (n = 35). Cone-beam computed tomography scans were analysed by using scores as defined by Lund and Mackay and by Kennedy. Our results show a 5 times greater odds (p = 0.01) for developing nasal polyposis in the presence of lowered estradiol plasma levels than in the presence of normal / elevated levels. When analyzing females and males separately, a 6 times greater odds for females to develop nasal polyposis in the presence of lowered estradiol plasma levels was calculated (p = 0.02). Thus, females are more likely to develop nasal polyposis when they have lowered estradiol levels than males. In addition, female patients showed an increased risk for developing ASA intolerance (p = 0.01). Variation of sex hormones may be involved in nasal polyposis. Further studies including more patients to validate the presented results are required. Retrospective clinical investigation suggesting a correlation between varying sex hormones and nasal polyposis.


Julia Espersen, Ursula Weber, Ariane Römer-Franz, Thomas Lenarz, Stefan R O Stolle, Athanasia Warnecke. Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis. PloS one. 2020;15(12):e0243732

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PMID: 33332460

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