Research progress on the regulation mechanism of Pseudomonas aeruginosa biofilm].

Z J Zhao, X W Liu, X Q Zhang, M Y Guo, Y Hu, D M Liu, Y W Li

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 2020 Dec 06

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Pseudomonas aeruginosa is one of the common multidrug-resistant bacteria in the clinic. Because it can produce a "protective" biofilm, it can affect the penetration and killing efficacy of antibacterial drugs, leading to the formation of a persistent and persistent chronic infection in the host. Biofilms make Pseudomonas aeruginosa resistant to antibacterials and evasive to the host's immune system. Therefore, traditional conventional antibacterials are difficult to achieve effective bactericidal treatment. Understanding the process of P. aeruginosa biofilm formation and the regulatory mechanisms that affect biofilms can provide ideas and methods for our future research on new antibacterial drugs.

Citation

Z J Zhao, X W Liu, X Q Zhang, M Y Guo, Y Hu, D M Liu, Y W Li. Research progress on the regulation mechanism of Pseudomonas aeruginosa biofilm]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2020 Dec 06;54(12):1469-1472