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Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way. Those FG-Nups have been demonstrated to participate in various biological processes besides nucleocytoplasmic transport. The high number of accessible hydrophobic motifs of FG-Nups potentially gives rise to this multifunctionality, enabling them to form unique microenvironments. In this review, we discuss the multifunctionality of disordered and F-rich Nups and the diversity of their localizations, emphasizing the important roles of those Nups in various regulatory and metabolic processes. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.


Nike Heinß, Mikhail Sushkin, Miao Yu, Edward A Lemke. Multifunctionality of F-rich nucleoporins. Biochemical Society transactions. 2020 Dec 18;48(6):2603-2614

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PMID: 33336681

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