Yoko Tanabe, Kazuhiro Shimizu, Emi Kondo, Mikinobu Yasumatsu, Daisuke Nakamura, Hiroyuki Sagayama, Hideyuki Takahashi
Journal of strength and conditioning research 2021 Feb 01Tanabe, Y, Shimizu, K, Kondo, E, Yasumatsu, M, Nakamura, D, Sagayama, H, and Takahashi, H. Urinary N-terminal fragment of titin reflects muscle damage after a soccer match in male collegiate soccer players. J Strength Cond Res 35(2): 360-365, 2021-Previous studies have demonstrated that noninvasive urinary N-terminal fragment of titin (U-titin) concentration highly correlates with serum creatine kinase (CK) activity, a classic invasive muscle damage marker. This finding indicates that U-titin could be used to estimate muscle damage. However, these results were achieved using a laboratory-based eccentric exercise model. Therefore, it remains unclear whether U-titin is useful for evaluating muscle damage occurring in field sports events. As a result, we evaluated whether U-titin concentration closely relates to serum CK activity after a soccer match. Seventeen collegiate soccer players (age: 20 ± 1 year; height: 172 ± 6 cm; body mass: 65 ± 5 kg; Yo-Yo intermittent recovery test level 2, 1,135 ± 196 m) completed a test match (2 halves of 45 minutes separated by 15 minutes of normal half-time). U-titin concentration, serum CK activity, countermovement jump performance, and muscle soreness were assessed 2 hours before the match and 30 minutes, 24 hours, and 48 hours after the match. U-titin concentrations and CK activity similarly increased at 24 hours and returned to the baseline value at 48 hours after the match. Moreover, the percentage of changes in U-titin concentration from baseline after the match significantly and positively correlated with serum CK activity (r = 0.82, p < 0.05). These results suggest that the noninvasive marker U-titin can be used to assess muscle damage conditions in field sports events, such as soccer matches. Copyright © 2020 National Strength and Conditioning Association.
Yoko Tanabe, Kazuhiro Shimizu, Emi Kondo, Mikinobu Yasumatsu, Daisuke Nakamura, Hiroyuki Sagayama, Hideyuki Takahashi. Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players. Journal of strength and conditioning research. 2021 Feb 01;35(2):360-365
PMID: 33337691
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