Phenformin: AMP(K)ed for Potential Repurposing.

Joo Jung, Wendy B Bollag

The Journal of investigative dermatology 2021 Jan

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The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.