Bromodomain-containing protein 4 and its role in cardiovascular diseases.

Bromodomain-containing protein 4 (BRD4), a chromatin-binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy. This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future. © 2020 Wiley Periodicals LLC.

Citation

Liang Li, Wei Xie, Yu Gui, Xi-Long Zheng. Bromodomain-containing protein 4 and its role in cardiovascular diseases. Journal of cellular physiology. 2021 Jul;236(7):4829-4840

Mesh Tags

Substances

PMID: 33345363

search → result