Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy.

Ming-Hsien Lin, Julia Yu-Yun Lee, Shin-Chen Pan, Tak-Wah Wong

Photodiagnosis and photodynamic therapy 2021 Mar

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Chronic leg ulcers effect millions of people around the world. It is imperative to search for effective treatments for such challenging ulcers. We report the success of aminolevulinic acid-mediated antimicrobial photodynamic therapy (A-PDT) to enhance wound healing of chronic ulcers for 3 patients who were refractory to conventional treatments. These ulcers healed after one to three sessions of A-PDT and there was no recurrence for more than 29 months. Interestingly, no bacteria were isolated from the ulcers after A-PDT treatment. In vitro, A-PDT also inactivated all bacteria isolated from the patients. A-PDT conditioned medium containing IL-6 enhanced keratinocyte migration. The results suggest in addition to bactericidal effects, A-PDT also alters the wound microenvironment. A-PDT may be an effective treatment for patients with recalcitrant infected ulcers. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Ming-Hsien Lin, Julia Yu-Yun Lee, Shin-Chen Pan, Tak-Wah Wong. Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy. Photodiagnosis and photodynamic therapy. 2021 Mar;33:102149