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    Analog DNA strand displacement circuits can be used to build artificial neural network due to the continuity of dynamic behavior. In this study, DNA implementations of novel catalysis, novel degradation and adjustment reaction modules are designed and used to build an analog DNA strand displacement reaction network. A novel adaptive linear neuron (ADALINE) is constructed by the ordinary differential equations of an ideal formal chemical reaction network, which is built by reaction modules. When reaction network approaches equilibrium, the weights of the ADALINE are updated without learning algorithm. Simulation results indicate that, ADALINE based on the analog DNA strand displacement circuit has ability to implement the learning function of the ADALINE based on the ideal formal chemical reaction networks, and fit a class of linear function.


    Chengye Zou, Xiaopeng Wei, Qiang Zhang, Changjun Zhou. A Novel Adaptive Linear Neuron Based on DNA Strand Displacement Reaction Network. IEEE/ACM transactions on computational biology and bioinformatics. 2022 May-Jun;19(3):1424-1434

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    PMID: 33347411

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