Neuromodulatory pathways in learning and memory: Lessons from invertebrates.

In an ever-changing environment, animals have to continuously adapt their behaviour. The ability to learn from experience is crucial for animals to increase their chances of survival. It is therefore not surprising that learning and memory evolved early in evolution and are mediated by conserved molecular mechanisms. A broad range of neuromodulators, in particular monoamines and neuropeptides, have been found to influence learning and memory, although our knowledge on their modulatory functions in learning circuits remains fragmentary. Many neuromodulatory systems are evolutionarily ancient and well-conserved between vertebrates and invertebrates. Here, we highlight general principles and mechanistic insights concerning the actions of monoamines and neuropeptides in learning circuits that have emerged from invertebrate studies. Diverse neuromodulators have been shown to influence learning and memory in invertebrates, which can have divergent or convergent actions at different spatiotemporal scales. In addition, neuromodulators can regulate learning dependent on internal and external states, such as food and social context. The strong conservation of neuromodulatory systems, the extensive toolkit and the compact learning circuits in invertebrate models make these powerful systems to further deepen our understanding of neuromodulatory pathways involved in learning and memory. © 2020 British Society for Neuroendocrinology.

Citation

Sara Van Damme, Nathan De Fruyt, Jan Watteyne, Signe Kenis, Katleen Peymen, Liliane Schoofs, Isabel Beets. Neuromodulatory pathways in learning and memory: Lessons from invertebrates. Journal of neuroendocrinology. 2021 Jan;33(1):e12911

Mesh Tags

Substances

PMID: 33350018

search → result