Study advance in biosynthesis of flavone from Scutellaria].

Fang Yu-Min, Cui Meng-Ying, Liu Jie, Pei Tian-Lin, Wei Yu-Kun, Zhao Qing

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2020 Oct

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Flavones are widely distributed in terrestrial plants and act as important bioactive compounds in medicinal plants. Baicalein, wogonin and their glycosides baicalin and wogonoside are major active components found in medicinal plant Scutellaria baicalensis. These flavones can induce apoptosis in various cancer cell lines, with such pharmacological activities as anti-oxidation, antivirus and liver protection. In recent years, the biosynthesis pathways of flavones in Scutellaria have been studied thoroughly. In particular, the biosynthesis pathways of baicalein and wogonin in S. baicalensis were interpreted completely. In this review, the biosynthesis of flavones in Scutellaria, the regulation of environmental factors and elicitors on their biosynthesis, and the metabolic engineering of the flavones were discussed.

Citation

Fang Yu-Min, Cui Meng-Ying, Liu Jie, Pei Tian-Lin, Wei Yu-Kun, Zhao Qing. Study advance in biosynthesis of flavone from Scutellaria]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Oct;45(20):4819-4826