Mihoko Sasahara, Takashi Abe, Yoichi Otomi, Hiroki Yamazaki, Masafumi Harada
Clinical nuclear medicine 2021 Mar 01A 30-year-old man presented with repeated episodes of painless injuries in his feet and abnormally high body temperature. He was diagnosed with congenital insensitivity to pain with anhidrosis-a rare hereditary peripheral neuropathy characterized by decreased pain, reduced sweating, and autonomic neuropathy. Congenital insensitivity to pain with anhidrosis is also called hereditary sensory and autonomic neuropathy type IV. 123I-MIBG myocardial scintigraphy showed reduced myocardial uptake (heart-to-mediastinum ratio: 1.56 and 1.42 in the early and late phases, respectively; washout ratio, 49%), indicating autonomic dysfunction. This finding may contribute to the diagnosis of congenital insensitivity to pain with anhidrosis and the semiquantitative evaluation of an autonomic dysfunction. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Mihoko Sasahara, Takashi Abe, Yoichi Otomi, Hiroki Yamazaki, Masafumi Harada. Reduced Myocardial Uptake of 123I-MIBG in Congenital Insensitivity to Pain With Anhidrosis. Clinical nuclear medicine. 2021 Mar 01;46(3):227-228
PMID: 33351513
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