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One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an anti-mitotic cancer therapy. Copyright © 2020 Elsevier Inc. All rights reserved.
Citation
Alexsandro Dos Santos, Sabine Elowe. Moonlighting at the Centrosome: RXRα Turns to Plk1. Developmental cell. 2020 Dec 21;55(6):672-674
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PMID: 33352140
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