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    FTIR spectroscopy is a common in situ reaction monitoring technique used in modern academic and industrial environments. The FTIR signals collected during the course of a reaction are proportional to the concentration of the reaction components but not intrinsically quantitative. To make FTIR data quantitative, precalibration or offline analyses of reaction samples are required, which diminishes the unique benefits of in situ reaction monitoring techniques. Herein, we report the use of standard addition as a convenient method to obtain quantitative FTIR data.


    George Hutchinson, Calum D M Welsh, Jordi Burés. Use of Standard Addition to Quantify In Situ FTIR Reaction Data. The Journal of organic chemistry. 2021 Jan 15;86(2):2012-2016

    PMID: 33356249

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