Effect of tadalafil 5mg daily treatment on penile haemodynamics in patients with erectile dysfunction].

Phosphodiesterase-5 inhibitors (PDE-5) are the first-line treatment. ED diagnostic and evaluation methods are clinical: erection self-perception and evaluation questionnaires. It is necessary to identify predictive markers to choose the best drug and the best dose for each individual patient. This study seeks to evaluate the effect of tadalafil 5mg daily treatment on penile haemodynamics (penis in flaccidity, using doppler ultrasound, without using alprostadil) and to study if these changes are clinically associated. 40 patients who started treatment with tadalafil 5mg daily were consecutively selected in a prospective study. Each patient underwent a penile doppler ultrasound and completed questionnaires (IIEF-6, EHS, SEP-2, SEP-3) at three different times: before starting the treatment, at 3 months and at 6 months (within the last 30 days without treatment). Tadalafil 5mg daily treatment for 3 months did not result in significant modifications to VPS and AS. There was clinical improvement according to the questionnaires after three months of treatment, which was not maintained at 6 months. Neither a clinical-radiological correlation nor a haemodynamic value predicting response to treatment could be established. Copyright © 2020 Asociación Española de Andrología, Medicina Sexual y Reproductiva. Publicado por Elsevier España, S.L.U. All rights reserved.

Citation

Carlos Gasanz, Daniel Moreno-Mendoza, Juan Fernando Villegas, María Fernanda Peraza, Joaquim Sarquella, Eduard Ruiz-Castañé, Josvany Sánchez-Curbelo. Effect of tadalafil 5mg daily treatment on penile haemodynamics in patients with erectile dysfunction]. Revista internacional de andrologia. 2022 Jan-Mar;20(1):49-53

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PMID: 33358311

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