Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola.

Ping-Chung Kuo, Shih-Huang Tai, Ching-Che Hung, Tsong-Long Hwang, Liang-Mou Kuo, Sio Hong Lam, Kun-Ching Cheng, Daih-Huang Kuo, Hsin-Yi Hung, Tian-Shung Wu

Bioorganic chemistry 2021 Mar

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Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Ping-Chung Kuo, Shih-Huang Tai, Ching-Che Hung, Tsong-Long Hwang, Liang-Mou Kuo, Sio Hong Lam, Kun-Ching Cheng, Daih-Huang Kuo, Hsin-Yi Hung, Tian-Shung Wu. Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola. Bioorganic chemistry. 2021 Mar;108:104562