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Neutralization of hemostatic disorders induced by Lachesis muta venom using Brazilian antivenoms.

Emiro G Muniz, Maria das Dores N Noronha, Maria das Graças G Saraiva, Wuelton Marcelo Monteiro, Sâmella S Oliveira

Toxicon : official journal of the International Society on Toxinology 2021 Feb


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    We characterized the hemorrhagic, coagulant and defibrinogenant activities of Lachesis muta venom and evaluated the capacity of the Brazilian antivenoms in neutralizing these activities. The hemorrhagic activity of L. muta venom was similarly neutralized by Bothrops, Bothrops-Lachesis and Bothrops-Crotalus antivenoms. The coagulant and defibrinogenant activities were better neutralized by the Bothrops-Lachesis antivenom. Bothrops-Crotalus antivenom also neutralized these activities, indicating that it can be an alternative to treat Lachesis envenomations when Bothrops-Lachesis antivenom is unavailable. Copyright © 2020 Elsevier Ltd. All rights reserved.

    Citation

    Emiro G Muniz, Maria das Dores N Noronha, Maria das Graças G Saraiva, Wuelton Marcelo Monteiro, Sâmella S Oliveira. Neutralization of hemostatic disorders induced by Lachesis muta venom using Brazilian antivenoms. Toxicon : official journal of the International Society on Toxinology. 2021 Feb;191:44-47

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    PMID: 33359389

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