Clusterin: Always protecting. Synthesis, function and potential issues.

Carmen Rodríguez-Rivera, Miguel M Garcia, Miguel Molina-Álvarez, Carmen González-Martín, Carlos Goicoechea

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Feb

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In the last years, clusterin, a challenging and paradoxical apolipoprotein, has been of growing interest amongst a rising number of scientists. This enigmatic protein is present in all fluids of the organism besides within the intracellular matrix, and it plays diverse, and at times contrary, roles in a growing number of pathologies. It seems to vary its location and function to assure cellular survival being cytoprotective hence its significance in neuroprotection and cancer along with chemotherapy resistance. However, it can also lead to cellular arrest and its modulation to apoptosis. Additionally, it has been described to modulate pain, as well as linked to inflammation, cardioprotection, satiety and hunger, and possibly to addictive behaviour development. Thus, it has been postulated to be used both as a biomarker and a very explorable new therapeutic target for several conditions. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Carmen Rodríguez-Rivera, Miguel M Garcia, Miguel Molina-Álvarez, Carmen González-Martín, Carlos Goicoechea. Clusterin: Always protecting. Synthesis, function and potential issues. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Feb;134:111174