The role of soluble E-selectin in HIV associated preeclampsia.

Girija Naidoo, Olive P Khaliq, Jagidesa Moodley, Thajasvarie Naicker

European journal of obstetrics, gynecology, and reproductive biology 2021 Feb

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To determine the serum concentration of soluble E-selectin (sE-selectin) in HIV associated preeclampsia. The study population (n = 72) consisted of normotensive pregnant (n = 36) and preeclamptic (n = 36) women stratified by HIV status (negative vs. positive). Serum concentrations of sE-selectin were quantified using the MilliPlex multiplex immunoassay method. Statistical analyses were conducted using GraphPad Prism software. When stratified by pregnancy type and HIV status, serum sE-selectin levels were elevated in the preeclamptic HIV-negative group compared to the normotensive HIV-negative group (p = 0.0070**). Gestational age, systolic blood pressure, diastolic blood pressure and baby weight were statistically different across the study groups (p < 0.0001). This study demonstrates an elevation of sE-selectin in preeclamptic HIV-negative compared to the normotensive HIV-negative group. However, when stratified by HIV status, there was no significant difference observed in preeclamptic HIV-positive and normotensive HIV-positive groups. The findings of this small-scale study suggest that sE-selectin may be used as a biomarker or an early identifier of preeclampsia. Studies with large numbers should be considered to confirm our findings. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Girija Naidoo, Olive P Khaliq, Jagidesa Moodley, Thajasvarie Naicker. The role of soluble E-selectin in HIV associated preeclampsia. European journal of obstetrics, gynecology, and reproductive biology. 2021 Feb;257:64-69