Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen.

Zhang Yiming, Yin Hang, Shao Bing, Xue Hua, Huang Bo, Liu Honggui, Li Shu

Ecotoxicology and environmental safety 2021 Feb

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Cadmium (Cd) is a toxic trace element that can enter the environment with industrial waste and accumulate in the body but the health effects of Cd on ternary pigs are still lacking in research. In order to explore the effect of Cd on the apoptosis of pig spleen and its mechanism, this study chose ternary pig as the research object to detect relevant indicators in pig spleen under Cd exposure. The results of this study showed that Cd exposure can induce apoptosis by promoting the absorption of various toxic trace elements in the spleen and inducing oxidative stress. We also found that the mechanism of Cd-induced apoptosis is closely related to the VDR/CREB1 pathway. On the one hand, Cd exposure can activate VDR, and indirectly regulate the CYP family, affecting the normal function of the spleen. On the other hand, VDR and its downstream genes antagonize the toxicity of Cd by maintaining the stability of the mitochondrial-related endoplasmic reticulum membrane structure. Our research will help researchers to further understand the physiological toxicity of Cd. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Zhang Yiming, Yin Hang, Shao Bing, Xue Hua, Huang Bo, Liu Honggui, Li Shu. Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen. Ecotoxicology and environmental safety. 2021 Feb;209:111819