Target specific aptamer-induced self-assembly of fluorescent graphene quantum dots on palladium nanoparticles for sensitive detection of tetracycline in raw milk.

The excessive use of tetracyclines (TCs), a bacteriostaticantibiotic, in food products, has led to the accumulation of TCs residues in the human body, affecting human health seriously. Therefore, the development of a highly sensitive method to detect TCs in food is of utmost importance. This study reports a novel sensing strategy using aptamer-induced fluorescence fluctuation of graphene quantum dots (GQDs) and palladium nanoparticles (Pd NPs) for the rapid and label-free detection of tetracycline with a limit of detection of 45 ng.mL-1. A novel single-step synthesis of positively charged Pd NPs and one-step green synthesis of GQDs directly from graphite has been developed. The proposed strategy provides an efficient way to detect low traces of TCs and a new technique for the development of aptamer-based sensors. Copyright © 2020 Elsevier Ltd. All rights reserved.

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Syed Rahin Ahmed, Satish Kumar, Greter A Ortega, Seshasai Srinivasan, Amin Reza Rajabzadeh. Target specific aptamer-induced self-assembly of fluorescent graphene quantum dots on palladium nanoparticles for sensitive detection of tetracycline in raw milk. Food chemistry. 2021 Jun 01;346:128893

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PMID: 33387835

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