Biological characteristics of IL-6 and related intestinal diseases.

Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-Jun Yang, Fei-Fei Wang, Hong-Wei Shang, Rongxuan Hua, Jing-Dong Xu

International journal of biological sciences 2021

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The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process. © The author(s).

Citation

Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-Jun Yang, Fei-Fei Wang, Hong-Wei Shang, Rongxuan Hua, Jing-Dong Xu. Biological characteristics of IL-6 and related intestinal diseases. International journal of biological sciences. 2021;17(1):204-219