Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity.

Supakorn Arthan, Chanakan Pornchoo, Auemduan Prawan, Sarawut Tontapha, Vittaya Amornkitbamrung, Chavi Yenjai

Natural product research 2022 Mar

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A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC50 values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones 2, 14, 16 and 18 as well as flavones 5, 6 and 12 showed moderate cytotoxicity with IC50 values ranging from 5.39 to 14.00 µg/mL.[Formula: see text].

Citation

Supakorn Arthan, Chanakan Pornchoo, Auemduan Prawan, Sarawut Tontapha, Vittaya Amornkitbamrung, Chavi Yenjai. Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity. Natural product research. 2022 Mar;36(5):1236-1244