Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1.

Brevibacterium linens AE038-8 is an arsenic hyper-tolerant bacterial strain, previously isolated from well water in Tucumán, Argentina. The aim of this study was to characterize this strain regarding its resistance to different stress factors and to evaluate its antiviral activity against Herpes simplex virus type 1 (HSV-1). We found that B. linens AE038-8 was capable of tolerating high concentrations of heavy metals such as Cd(II), Cr(VI) and Cu(II). When grown in the presence of NaCl, it could tolerate up to 3 M in LB25 medium. When cultivated, B. linens released to the supernatants a bioactive principle with antiviral activity against HSV-1 virus regardless growth conditions.

Citation

Daniela Maizel, Franco Maximiliano Salinas, Inés Solórzano, Laura Raiger Iustman, Marcela Alejandra Ferrero, Pablo Jacobo David Mauas, Laura Edith Alché. Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1. Current microbiology. 2021 Feb;78(2):688-695

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PMID: 33399943

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