Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro.

Ming Zhang, Yuwei Zhang, Qiqi Huang, Hui Duan, Guodong Zhao, Lei Liu, Yuxin Li

Bioorganic & medicinal chemistry letters 2021 Mar 01

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Seventeen flavonoids (1-17) were isolated from Sophora alopecuroides L.. Compounds 1 and 2 were new compounds, and compounds 5, 8, 11, 12, and 17 were isolated from S. alopecuroides for the first time. The sources of compounds 1 and 2 were determined from the seeds of S. alopecuroides by UPLC-QE-Orbitrap-MS, and compounds 1, 2, 7, 13, 14, 15, 16, and 17 were proven to improve the insulin resistance of C2C12 myotubes and significantly increase glucose consumption levels. Among them, compounds 1, 2, 13, 14, 16, and 17 could bind to protein tyrosine phosphatase 1B (PTP1B), thereby significantly inhibiting the enzyme activity of PTP1B. Compound 2 had the strongest inhibitory effect, with an inhibition rate of 95.22% at 0.1 μg mL-1. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Ming Zhang, Yuwei Zhang, Qiqi Huang, Hui Duan, Guodong Zhao, Lei Liu, Yuxin Li. Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro. Bioorganic & medicinal chemistry letters. 2021 Mar 01;35:127775