Cross-sectional study based on occupational aluminium exposure population.

Shi-Meng Xu, Yun-Wei Zhang, Xiao-Fen Ju, Dan Gao, Hui Yang, Lin-Ping Wang, Jing Song, Qin-Li Zhang, Nan Shang, Qiao Niu, Xiao-Ting Lu

Environmental toxicology and pharmacology 2021 Apr

filter terms:

To evaluate the different characteristics of cognitive impairment caused by occupational aluminium exposure at different ages, we surveyed 1660 workers in Shanxi Aluminium Plant, China, and assessed their cognitive function and plasma aluminium concentration. In multiple linear regression, the scores of the digit-span test (DST) and digit-span backward test (DSBT) were negatively correlated with plasma aluminium concentration when concentration reached 34.52 μg/L in younger group (＜40 years), while in the middle-aged group (≥40 years) only found when concentration reached 42.25 μg/L (β<0, P < 0.05). In logistic regression, when plasma aluminum concentration reached 42.25μg/L, odds ratios (95 % confidence interval) were 1.695 (1.062-2.705) and 3.270 (1.615-6.620) for DST, 7.644 (3.846-15.192) and 15.308 (4.180-56.059) for DSBT in middle-aged group and younger group, respectively. These results showed that aluminium exposures were associated with cognitive impairment among aluminium-exposed workers, particularly for young workers who were more susceptible. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Shi-Meng Xu, Yun-Wei Zhang, Xiao-Fen Ju, Dan Gao, Hui Yang, Lin-Ping Wang, Jing Song, Qin-Li Zhang, Nan Shang, Qiao Niu, Xiao-Ting Lu. Cross-sectional study based on occupational aluminium exposure population. Environmental toxicology and pharmacology. 2021 Apr;83:103581