Wnt5a Plays Controversial Roles in Cancer Progression.

Xu Chen, Hong Ling Liu, Feng Hui Zhao, Zong Xian Jiao, Jin Sui Wang, Ya Mei Dang

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2020 Dec 31

filter terms:

Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. Therefore, it is an essential factor in cancers' progression (invasion, migration, proliferation, and epithelial-mesenchymal transition), and a potential biomarker for prognosis and treatment.

Citation

Xu Chen, Hong Ling Liu, Feng Hui Zhao, Zong Xian Jiao, Jin Sui Wang, Ya Mei Dang. Wnt5a Plays Controversial Roles in Cancer Progression. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2020 Dec 31;35(4):357-365