Age-related alteration in HNE elimination enzymes.

Hongqiao Zhang, Todd E Morgan, Henry Jay Forman

Archives of biochemistry and biophysics 2021 Mar 15

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4-hydroxynonenal (HNE, 4-hydroxy-2-nonenal) is a primary α,β-unsaturated aldehyde product of lipid peroxidation. The accumulation of HNE increases with aging and the mechanisms are mainly attributable to increased oxidative stress and decreased capacity of HNE elimination. In this review article, we summarize the studies on age-related change of HNE concentration and alteration of HNE metabolizing enzymes (GCL, GST, ALDHs, aldose reductase, and 20S-proteasome), and discuss potential mechanism of age-related decrease in HNE-elimination capacity by focusing on Nrf2 redox signaling. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Hongqiao Zhang, Todd E Morgan, Henry Jay Forman. Age-related alteration in HNE elimination enzymes. Archives of biochemistry and biophysics. 2021 Mar 15;699:108749