The racemic trimeric quinone and polycyclic quinones isolated from the aerial parts of Morinda umbellata L.

Four undescribed racemic quinones, umbellatas Q-T, were isolated from the aerial parts of Morinda umbellata L. All enantiomers were separated on a chiral HPLC column, and their structures were elucidated by UV spectroscopy, IR spectroscopy, HR-ESI-MS, 1D and 2D NMR spectroscopy, DP4+ NMR calculations, ECD spectroscopy, and X-ray diffraction. Three of the racemes are polycyclic anthraquinones, and one is a rare racemic trimer of naphthoquinone-bisnaphthohydroquinones. (+)-Umbellata S exhibited potent cytotoxicity (IC50: 6.2-9.3 μM) against the A2780, HeLa, H7420, Ketr3 and SW 1990 human cancer cell lines. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Changkang Li, Chaoxuan Dong, Jia Fu, Jun Xie, Shengtian Lai, Hongqing Wang, Ruoyun Chen, Jie Kang. The racemic trimeric quinone and polycyclic quinones isolated from the aerial parts of Morinda umbellata L. Phytochemistry. 2021 Mar;183:112622

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PMID: 33418168

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