Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.

Guosong Wang, Ruiqi Chen, Pengfei Huang, Junping Hong, Jiali Cao, Qian Wu, Wei Zheng, Lina Lin, Qiangyuan Han, Yixin Chen, Ningshao Xia

Antiviral research 2021 Feb

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Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in humans or pigs. Thus, it is important to develop a new effective drug for the treatment of PRV infection. To this end, we established a novel rapid method to screen drugs against PRV from 1818 kinds of small molecular drugs approved by the FDA. Using this method, we identified 21 kinds of them that can strongly suppress the proliferation of PRV. Mitoxantrone, puromycin dihydrochloride, mitoxantrone hydrochloride and adefovir dipivoxil effectively inhibited PRV in vitro. Of them, only adefovir dipivoxil could potently protect mice against lethal PRV infection. Our work identifies several kinds of potential therapeutics against PRV and may offer important guidance for controlling PRV epidemics and treating associated diseases in humans and animals. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Guosong Wang, Ruiqi Chen, Pengfei Huang, Junping Hong, Jiali Cao, Qian Wu, Wei Zheng, Lina Lin, Qiangyuan Han, Yixin Chen, Ningshao Xia. Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo. Antiviral research. 2021 Feb;186:105014