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Acrylamide (AA) can have deleterious effects on freshwater fish. However, its adverse effects on euryhaline fish are still unknown. In this study, embryos of Oryzias melastigma were exposed to different concentrations of AA to investigate its effect on early developmental disorders. After 21 days of exposure, AA significantly inhibited the hatching rate and delayed the hatching time of embryos, and led to developmental delay, teratogenesis, and locomotion impairments in larvae. RNA-sequencing data of larvae indicated that AA upregulated the expression of hemoglobin and myoglobin involved in oxygen transport and angiopoietin 1, integrin, and matrix metallopeptidases related to angiogenesis and downregulated the expression of early growth response genes and synaptotagmin-2 related to neural plasticity and neurotransmitter release. Overall, our study showed that AA caused deleterious effects on the early development of euryhaline fish through hypoxic stress and neurotoxicity, providing a scientific basis for the environmental risk assessment of marine AA. Copyright © 2020 Elsevier Ltd. All rights reserved.


Zonghao Yue, Erli Tian, Yanjuan Chen, Liumin Luo, Licheng Yang, Le He, Lili Li, Jun Wang. The adverse effects of acrylamide exposure on the early development of marine medaka (Oryzias melastigma) and its mechanisms. Marine pollution bulletin. 2021 Feb;163:111875

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PMID: 33422830

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