Toll-like Receptor Agonists in Radiation Protection].

Jiao Guo, Hai Yu Yang, Wei Long

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2020 Dec 30

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Ionizing radiation causes the massive apoptosis of human tissue cells,leading to dysfunction of the gastrointestinal tract and hematopoietic system.Thus,high-efficiency,low-toxicity radiation protection drugs are urgently needed.Toll-like receptor agonists have been developed based on the anti-apoptotic mechanism of tumor cells in recent years,which exert their radioprotective effects by activating downstream pathways,mainly nuclear factor-κB.Here we elucidate several agonists of Toll-like receptors involved in radiation protection,with an attempt to inform the research and development of new radiation protection agents.

Citation

Jiao Guo, Hai Yu Yang, Wei Long. Toll-like Receptor Agonists in Radiation Protection]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2020 Dec 30;42(6):805-809