Correlation Engine 2.0
Clear Search sequence regions

  • adult (2)
  • antibodies (2)
  • antigens viral (3)
  • child (1)
  • children (1)
  • female (1)
  • fever (1)
  • humans (1)
  • india (2)
  • pregnancy (1)
  • pregnant women (1)
  • rubella (3)
  • rubella virus (3)
  • serum (1)
  • skin rashes (1)
  • strain (2)
  • vaccines (1)
  • Sizes of these terms reflect their relevance to your search.

    Rubella, is a contagious disease caused by Rubella virus (RuV) that manifests as fever with skin-rashes in children and adults along with complications in pregnant women. WHO-SEAR has set a target for Rubella elimination by 2023. This is the first report of antigenic characterization and genome sequencing of nine RuVs sampled during 1992, 2007-9, and 2015-17 from four Indian states. Comparative analysis of Indian RuVs (2B) with that of global isolates and vaccine strain RA 27/3 (1a) revealed that the observed mutations in structural proteins have no major impact on the 3D structure, function and antigenicity. Indian RuVs formed three major clusters (Pune-1992, Kannur-2009 and Chitradurg-2007) in genome-based phylogeny of global isolates. Neutralizing antibody titers in a panel of serum samples from measles negative cases were significantly higher to the vaccine strain compared to a wild-type 2B isolate (Kannur) with concordance of 91.9%, thereby substantiating the use of current vaccines. Copyright © 2020 Elsevier Ltd. All rights reserved.


    Sunil R Vaidya, Sunitha M Kasibhatla, Madhukar B Kamble, Ashok Munivenkatappa, Neelakshi S Kumbhar, Manjunatha M Jayaswamy, Mukund R Ramtirthkar, Mohan M Kale, Urmila Kulkarni-Kale. Genetic and antigenic characterization of wild type rubella viruses isolated from India. Vaccine. 2021 Feb 05;39(6):876-881

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33423836

    View Full Text